2025 Summer Intern - Drug Metabolism and Pharmacokinetics - Quantitative Metabolomics

2025 Summer Intern - Drug Metabolism and Pharmacokinetics - Quantitative Metabolomics

Department Summary

The Drug Metabolism and Pharmacokinetics (DMPK) Department at Genentech Research and Early Development (gRED) holds a vision to advance the development of safe and efficacious life-changing therapeutics for patients as an integral partner. The Metabolomics and Lipidomics Group under Bioanalysis Function supports research biology, drug discovery and development across Genentech by generating high-quality metabolomics and lipidomics data through the use of state-of-the-art technologies and high-throughput workflows and deciphering biochemical insights for target assessment and biomarker discovery.

This internship position is located in South San Francisco CA, on-site.

The Opportunity

The candidate will support the development and evaluation of quantitative assays for global metabolomics by using various liquid chromatography-mass spectrometry (LC-MS) instruments and data processing tools. This position provides an opportunity to significantly advance cutting-edge metabolomics workflows and impact on enhancing reproducibility and standardization of metabolomics assay for research and drug discovery projects. The key responsibilities of the intern are:

• Implement and assess different analytical strategies to build a quantitative metabolomics assay for common biological matrices.

• Establish and apply QC metrics to evaluate accuracy, precision, sensitivity, reproducibility, and robustness of the assay.

• Standardize and automate data analysis workflow to streamline quality check and expand throughout while maintaining high quality.

• Incorporating the quantitative workflow into project support for in-house studies.

Program Highlights

• Intensive 12-weeks, full-time (40 hours per week) paid internship.

• Program start dates are in May/June (Summer), 2025.

• A stipend, based on location, will be provided to help alleviate costs associated with the internship.

• Ownership of challenging and impactful business-critical projects.

• Work with some of the most talented people in the biotechnology industry.

• Professional & personal development curriculum throughout the program, including networking opportunities, workshops, and panel discussions.

Who You Are (Required)

Required Education

• Must be pursuing a PhD (enrolled student)

Required Majors: Chemistry, Chemical Engineering, Biochemistry, Pharmaceutical Science or related discipline.

Required Skills:

• Hands-on experience with sample preparation techniques and LC-MS with a focus on metabolomics, lipidomics, or small-molecule bioanalysis.

• Proficiency in processing metabolomics MS raw data and quantitative analysis.

• Experience in R or Python for data analysis and visualization.

• Team collaboration and the ability to work independently.

Preferred Knowledge, Skills, and Qualifications

• Prior experience with studying cellular and/or organismal metabolism is a plus.

• Excellent communication, collaboration, and interpersonal skills.

• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting.

The expected salary for this position based on the primary location of California is $45 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.